Padmanābhan was born in 1869, near Panayannaarkavu, at the Central Travancore city of Mannar, at Kaavil, his mother's ancestral home. His dad was Sankaran Vaidyar Mooloor and his mother was Amma Veluthakunj. His parents were both well-educated, prosperous and respected. Kaavil was a family of traditional Ayurvedic practitioners, and the Mooloor family is well-known to be human, Sanskrit and spiritual.
The reason behind the 1936 Declaration of the Temple of Entry, which abolished the ban on low-caste people who entry into the Hindu temples of Travancore, was considered as Kavi-Ramayanam, his literary masterpiece, he writes at the age of 25.
In a small hamlet in Mezhuveli, he was the first editor of the daily Kerala Kaumudi and the founder of the 78-year-old Padmanabhodayam School. He was named for Sree Moolam Praja Sabha by the Government of Travancore, precursor to the new Legislative Assembly. In the twenty-fifth year of his establishment, Mooloor was elected vice-chairman of the Sree Dharma Paripalana (SNDP) Yogam.